PMID: 16669754 妞嶇墿miRNA RNA娌夐粯 鍙戣偛 璋冩帶
Annu. Rev. Plant Biol. 2006. 57:19鈥53
MicroRNAs and Their Regulatory Roles in Plants
05骞寸殑缁艰堪锛岃櫧鐒跺湪small RNA浜х敓鍜岃皟鎺ф満鐞嗕笂寰堝 鍐呭宸叉洿鏂帮紝浣嗕綔涓轰竴绡囩爺绌舵鐗﹕mall RNA鐨勫叆闂ㄦ枃绔犺繕鏄緢濂界殑銆
MicroRNAs (miRNAs) 鏄皬鍐呮簮鎬NA鍦ㄦ鐗╁拰鍔ㄧ墿涓皟鑺傚熀鍥犺〃杈撅紝杩欎簺21nt鐨凴NA鐢辩被DICER閰朵粠闀跨殑鍒濆杞綍鏈笂鐨勮寧鐜粨鏋勪笂鍔犲伐鑰屾潵锛屽啀瀵煎叆娌夐粯澶嶅悎浣擄紝鍦ㄥ鍚堜綋涓垎瑁備簰琛ョ殑mRNA銆俶iRNA浠嬪鐨勫熀鍥犺皟鎺у妞嶇墿鍙戣偛杩涚▼鏈夐噸瑕佸奖鍝嶏紝澶氫互涓浜涚紪鐮佽浆褰曞洜瀛愬拰F锛峛ox铔嬬櫧浣滀负闈跺熀鍥犳潵锛岃岃繖浜涢澏鍩哄洜鎭版槸璋冩帶缃戠粶鐨勪腑蹇冪幆鑺傘
MicroRNAs (miRNAs) are small, endogenous RNAs that regulate
gene expression in plants and animals. In plants, these 鈭21- nucleotide RNAs are processed from stem-loop regions of long primary transcripts by a Dicer-like enzyme and are loaded into silencing complexes, where they generally direct cleavage of complementary mRNAs. Although plant miRNAs have some conserved functions extending beyond development, the importance of miRNA-directed gene regulation during plant development is now particularly clear. Identified in plants less than four years ago, miRNAs are already known to play numerous crucial roles at each major stage of development鈥攖ypically at the cores of gene regulatory networks, targeting genes that are themselves regulators, such as those encoding transcription factors and F-box proteins.
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