PMID: 20410883 RNA鑱氬悎閰禝I AGO铔嬬櫧 DNA鐢插熀鍖
Nature.聽 2010 Apr 21
An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation. [鍏ㄦ枃]
鏈卞仴搴凤紝涓涓猂NA鑱氬悎閰禝I鍜孉GO4鐩稿叧鐨勮泲鐧芥寚瀵糝NA浠嬪鐨凞NA鐢插熀鍖栥
浠ヤ笅鏄瀛︾綉鐨勪腑鏂囨姤閬擄細銆婅嚜鐒躲嬶細涓绉戝瀹跺彂鐜颁笌鍩哄洜鈥滄矇榛樷濇湁鍏崇壒娈婂熀鍥
濂ュ湴鍒╂牸闆锋垐灏斅烽棬寰峰皵妞嶇墿鍒嗗瓙鐢熺墿瀛︾爺绌舵墍鏃ュ墠瀹e竷锛屼竴涓寘鎷鐮旂┒鎵銆佷腑鍥藉悓娴庡ぇ瀛︺佺編鍥藉姞鍒╃灏间簹澶у绛夋満鏋勭瀛﹀鍦ㄥ唴鐨勫浗闄呯鐮斿皬缁勫彂鐜颁簡涓绉嶇壒娈婂熀鍥狅紝娌℃湁瀹冿紝妞嶇墿缁嗚優鍐呭叾浠栦竴浜涘熀鍥犲氨鍙兘淇濇寔娌夐粯銆
鏈鏂颁竴鏈熻嫳鍥姐婅嚜鐒躲嬫潅蹇楃綉缁滅増鍙戣〃浜嗚繖涓浗闄呯鐮斿皬缁勭殑璁烘枃銆傝繖涓绉戠爺灏忕粍鍙戠幇鐨勭壒娈婂熀鍥犲悕涓篟DM1锛屽畠鍙互缂栫爜鐢熸垚涓绉嶅皬铔嬬櫧锛屼粠鑰屽弬涓庢寚瀵煎叾浠栧熀鍥犵殑琛ㄨ揪銆
绉戝瀹舵寚鍑猴紝鍩哄洜涓鑸浜庤淇濇姢鐘舵佷腑锛屽彧鏈夐氳繃鎵璋撶殑鐢插熀鍖栵紝鍗充笌鐢插熀鎺ヨЕ锛屾墠鑳借〃杈惧苟鍙戞尌浣滅敤銆傚鏋滃幓闄DM1锛岃淇濇姢鐨勫熀鍥犲氨鏃犳硶鐢插熀鍖栵紝涔熷氨鏃犳硶杩涜琛ㄨ揪銆
鐢变簬姣忎竴涓鐗╃粏鑳炰腑閮藉瓨鍦ㄧ潃瀹屾暣鐨勯仐浼犱俊鎭紝鍥犳蹇呴』璁╂煇浜涘熀鍥犱繚鎸佲滄矇榛樷濓紝妞嶇墿鍏蜂綋鐨勫櫒瀹樻墠鑳介『鍒╁湴鍙戞尌鍚勮嚜浣滅敤銆傚惁鍒欙紝鎵鏈夊熀鍥犲氨浼氶兘鏉ヨ〃杈撅紝妞嶇墿鍣ㄥ畼涔熷皢涓嶇煡閬撳惉浠庤皝鐨勨滄寚浠も濄備竴鑸湪涓涓鐗╃殑涓婁竾涓熀鍥犻噷锛屽彧鏈夊緢灏戠殑涓閮ㄥ垎鑳藉琛ㄨ揪锛孯NA锛堟牳绯栨牳閰革級浼氬闇瑕佽〃杈剧殑鍩哄洜杩涜鏍囪銆俁DM1鍩哄洜鐨勪换鍔″氨鏄RNA鏍囪杩囩殑鍩哄洜琛ㄨ揪銆傜己灏戜簡RDM1锛屾鐗╀腑璁稿鏈琛ㄨ揪鐨勫熀鍥犲氨浼氫繚鎸佲滄矇榛樷濓紝妞嶇墿鏃犳硶姝e父鐢熼暱銆

璇勮 Comments